With the emergence of antibiotic resistance, there has been a rise in the pursuit of novel antimicrobial agents. Histone-derived antimicrobial peptides (HDAPs) have shown promise in combating antimicrobial resistance by acting against bacteria. Utilizing Histone subunits 3 and 4, proven to act against certain strains of bacteria, we developed a peptide library consisting of fragmented histones. The peptide library is studied to analyze trends in Histone properties and characteristics that might lead to the antimicrobial activity of the whole peptide.
